Are Biomarkers Predictive of Anthracycline-Induced Cardiac Dysfunction?
نویسندگان
چکیده
منابع مشابه
Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors.
PURPOSE To examine the utility and reliability of obtaining early echocardiographic measurements of left ventricular (LV) remodeling as well as blood biomarkers of cardiac injury in asymptomatic childhood cancer survivors at risk for LV dysfunction and congestive heart failure due to past exposure to anthracycline chemotherapy. EXPERIMENTAL DESIGN Using a cross-sectional design, anthracycline...
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Anthracyclines (i.e., doxorubicin, daunorubicin) have significant impact on outcome in many pediatric chemotherapy protocols and therefore remain the mainstay of treatment. The objective of this study was to identify the risk factors for anthracycline induced cardiac dysfunction in pediatric patients. Multiple logistic regression model was applied to assess the risk factors for development of c...
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Primary graft dysfunction (PGD) is a life-threatening complication among heart transplant recipients and a major cause of early mortality. Although the pathogenesis of PGD is still unclear, ischemia/reperfusion injury has been identified as a predominant factor. Both necrosis and apoptosis contribute to the loss of cardiomyocytes during ischemia/reperfusion injury, and this loss of cells can ul...
متن کاملCardiac Biomarkers and Myocardial Dysfunction in Septicemia.
Objectives Cardiac biomarkers have been studied in sepsis in the past and various mechanisms for their rise have been elucidated. However their association with severity of sepsis, mortality and myocardial dysfunction warrants further studies. We have studied three different cardiac biomarkers- troponin T (trop T), creatine phosphokinase MB isoform (CPK MB) and NT pro brain natriuretic peptide ...
متن کاملCardiac magnetic resonance characteristics of acute anthracycline-induced cardiotoxicity
Background Cardiac magnetic resonance imaging (CMR) is the gold standard for quantification of global and regional myocardial function and is able to detect subclinical myocardial dysfunction in the setting of a wide variety of myocardial disease processes, including anthracycline induced cardiomyopathy (AIC). Preliminary studies using T2-weighted sequences have demonstrated increase in signal ...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Cancer Prevention
سال: 2016
ISSN: 1513-7368
DOI: 10.7314/apjcp.2016.17.4.2301